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Mouse Anti-PGM1 Recombinant Antibody (3B8-H4) (CBMAB-P1592-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphoglucomutase 1. The antibody can be used for immunoassay techniques, such as ELISA, IF, IP, RNAi, WB.
See all PGM1 antibodies
Published Data
Fig.1 Western blot profiles of PGM1.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B8-H4
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IP, RNAi, WB

Basic Information

Immunogen
PGM1 (AAH19920, 1-562 aa) full length recombinant protein with GST tag. Immunogen sequence: MVKIVTVKTQ AYQDQKPGTS GLRKRVKVFQ SSANYAENFI QSIISTVEPA QRQEATLVVG GDGRFYMKEA IQLIARIAAA NGIGRLVIGQ NGILSTPAVS CIIRKIKAIG GIILTASHNP GGPNGDFGIK FNISNGGPAP EAITDKIFQI SKTIEEYAVC PDLKVDLGVL GKQQFDLENK FKPFTVEIVD SVEAYATMLR SIFDFSALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE LGAPANSAVN CVPLEDFGGH HPDPNLTYAA DLVETMKSGE HDFGAAFDGD GDRNMILGKH GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVASATKI ALYETPTGWK FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS ILATRKQSVE DILKDHWQKY GRNFFTRYDY EEVEAEGANK MMKDLEALMF DRSFVGKQFS ANDKVYTVEK ADNFEYSDPV DGSISRNQGL RLIFTDGSRI VFRLSGTGSA GATIRLYIDS YEKDVAKINQ DPQVMLAPLI SIALKVSQLQ ERTGRTAPTV IT
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-562

Target

Full Name
Phosphoglucomutase 1
Introduction
PGM1 is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.
Entrez Gene ID
5236
UniProt ID
P36871
Alternative Names
Phosphoglucomutase 1; Glucose Phosphomutase 1; EC 5.4.2.2; PGM 1; Phosphoglucomutase-1; EC 5.4.2; CDG1T; GSD14;
Function
This enzyme participates in both the breakdown and synthesis of glucose.
Biological Process
Carbohydrate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
GluconeogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Glucose metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Glycolytic processManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Congenital disorder of glycosylation 1T (CDG1T):
A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
PTM
Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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