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Mouse Anti-PHACTR1 Recombinant Antibody (E-2) (CBMAB-P1634-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatase And Actin Regulator 1. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PHACTR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
E-2
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphatase And Actin Regulator 1
Introduction
PHACTR1 is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection.
Entrez Gene ID
221692
UniProt ID
Q9C0D0
Alternative Names
Phosphatase And Actin Regulator 1; RPEL Repeat Containing 1; RPEL1; DJ257A7.2; KIAA1733; RPEL;
Function
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755).
Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Actin cytoskeleton reorganizationISS:UniProtKB
Actomyosin structure organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cell motilityManual Assertion Based On ExperimentIMP:UniProtKB
Cerebral cortex developmentISS:UniProtKB
Dendrite arborizationISS:UniProtKB
Regulation of neuron migrationISS:UniProtKB
Stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cell junction, synapse
Nucleus
Enriched at synapses (By similarity).
Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity).
Involvement in disease
Developmental and epileptic encephalopathy 70 (DEE70):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE70 is an autosomal dominant form with onset in first months of life and variable severity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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