Human PHACTR1 ELISA Kit (V2LY-0626-LY5017)

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Tested Data
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Basic Information

Sensitivity
0.0079 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
66.3 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Phosphatase And Actin Regulator 1
Function
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755).
Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Actin cytoskeleton reorganizationISS:UniProtKB
Actomyosin structure organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cell motilityManual Assertion Based On ExperimentIMP:UniProtKB
Cerebral cortex developmentISS:UniProtKB
Dendrite arborizationISS:UniProtKB
Regulation of neuron migrationISS:UniProtKB
Stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cell junction, synapse
Nucleus
Enriched at synapses (By similarity).
Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity).
Involvement in disease
Developmental and epileptic encephalopathy 70 (DEE70):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE70 is an autosomal dominant form with onset in first months of life and variable severity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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