Mouse Anti-PHC1 Recombinant Antibody (CBT3971) (V2LY-0625-LY8)

Name: Mouse Anti-PHC1 Recombinant Antibody (CBT3971)
SKU: V2LY-0625-LY8
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-PHC1 Recombinant Antibody (CBT3971) (V2LY-0625-LY8) in WB

Mouse Anti-PHC1 Recombinant Antibody (CBT3971) (V2LY-0625-LY8) in FC

Mouse Anti-PHC1 Recombinant Antibody (CBT3971) (V2LY-0625-LY8) in ELISA

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBT3971

Application

Immunogen

Purified recombinant fragment of human PHC1 (AA: 758-1004) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Polyhomeotic Homolog 1

Entrez Gene ID

1911

UniProt ID

P78364

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.

Biological Process

Histone ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Microcephaly 11, primary, autosomal recessive (MCPH11):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PHC1 (AA 758-1004) Recombinant Antibody (CBFYE-1588) (CAT#: CBMAB-E2245-FY)

Mouse Anti-PHC1 Recombinant Antibody (3G1) (CAT#: CBMAB-P1648-YC)

Mouse Anti-PHC1 Recombinant Antibody (1F3F3) (CAT#: CBMAB-P1647-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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