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Mouse Anti-PHC1 (AA 758-1004) Recombinant Antibody (CBFYE-1588) (CBMAB-E2245-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1588
Antibody Isotype
IgG1
Application
WB, FC, ELISA, CyTOF

Basic Information

Immunogen
Purified recombinant fragment of human PHC1 expressed in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 758-1004

Target

Full Name
Polyhomeotic Homolog 1
Introduction
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
Entrez Gene ID
1911
UniProt ID
P78364
Alternative Names
Polyhomeotic Homolog 1; Early Development Regulator 1 (Homolog Of Polyhomeotic 1); Early Development Regulatory Protein 1; HPH1; EDR1; Polyhomeotic Homolog 1 (Drosophila); Polyhomeotic-Like 1 (Drosophila)
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Biological Process
Histone ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Microcephaly 11, primary, autosomal recessive (MCPH11):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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