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Mouse Anti-PHKG2 Recombinant Antibody (1F9) (CBMAB-P1688-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphorylase Kinase Catalytic Subunit Gamma 2. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all PHKG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F9
Antibody Isotype
IgG2b
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-216

Target

Full Name
Phosphorylase Kinase Catalytic Subunit Gamma 2
Introduction
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Entrez Gene ID
5261
UniProt ID
P15735
Alternative Names
Phosphorylase Kinase Catalytic Subunit Gamma 2; Phosphorylase Kinase, Gamma 2 (Testis); Phosphorylase Kinase Subunit Gamma-2; PHK-Gamma-LT; EC 2.7.11.19; PHK-Gamma-T; PSK-C3; Phosphorylase B Kinase Gamma Catalytic Chain, Liver/Testis Isoform;
Function
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).
Biological Process
Generation of precursor metabolites and energyManual Assertion Based On ExperimentTAS:ProtInc
Glycogen biosynthetic processIEA:InterPro
Glycogen metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of glycogen catabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
cytosol
phosphorylase kinase complex
Involvement in disease
Glycogen storage disease 9C (GSD9C):
A metabolic disorder manifesting in infancy with hepatomegaly, growth retardation, hypotonia, liver dysfunction, and elevated plasma aminotransferases and lipids. These symptoms improve with age in most cases; however, some patients may develop hepatic fibrosis or cirrhosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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