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Rabbit Anti-Phospho-MPZL1 (Tyr241) Recombinant Antibody (D6F9) (CBMAB-CP2153-LY)

The product is antibody recognizes Phospho-MPZL1 (Tyr241). The antibody D6F9 immunoassay techniques such as: WB,IP,IF (ICC),FC.
See all Phospho-MPZL1 (Tyr241) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Cattle
Clone
D6F9
Antibody Isotype
IgG
Application
WB, IP, IF (ICC), FC

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr241 of human PZR protein.
Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Myelin Protein Zero Like 1
Introduction
MPZL1 (Myelin Protein Zero Like 1) is a Protein Coding gene. Diseases associated with MPZL1 include Noonan Syndrome 1. Among its related pathways are Tyrosine Kinases / Adaptors and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is MPZ.
Entrez Gene ID
Human9019
Mouse68481
Rat360871
Cattle539387
UniProt ID
HumanO95297
MouseQ3TEW6
RatQ6AYT8
CattleQ32PI9
Alternative Names
Myelin Protein Zero Like 1; PZR; Immunoglobulin Family Transmembrane Protein; Myelin Protein Zero-Like Protein 1; Protein Zero Related; Protein Zero-Related;
Function
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
Biological Process
Cell-cell signaling Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Cellular Location
Membrane
Involvement in disease
Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).
N-glycosylated. N-glycosylation is required for concanavalin A binding (PubMed:30392906).
Topology
Extracellular: 36-162
Helical: 163-183
Cytoplasmic: 184-269
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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