Phospho-MPZL1 (Tyr241)

MPZL1 (Myelin Protein Zero Like 1) is a Protein Coding gene. Diseases associated with MPZL1 include Noonan Syndrome 1. Among its related pathways are Tyrosine Kinases / Adaptors and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is MPZ.

Myelin Protein Zero Like 1

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Cell-cell signaling Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Membrane

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).
N-glycosylated. N-glycosylation is required for concanavalin A binding (PubMed:30392906).

Extracellular: 36-162
Helical: 163-183
Cytoplasmic: 184-269