Mouse Anti-PHOX2A Recombinant Antibody (4F6) (CBMAB-P1706-YC)

Name: Mouse Anti-PHOX2A Recombinant Antibody (4F6)
SKU: CBMAB-P1706-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

4F6

Application

IF, WB

Immunogen

PHOX2A (NP_005160, 1-91 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

paired-like homeobox 2a

Introduction

PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.

Entrez Gene ID

401

UniProt ID

O14813

Alternative Names

Paired Like Homeobox 2a; Aristaless Homeobox Protein Homolog; ARIX1 Homeodomain Protein; Paired-Like Homeobox 2A; PMX2A; ARIX; Aristaless (Drosophila) Homeobox, Aristaless Homeobox (Drosophila), Fibrosis Of Extraocular Muscles, Congenital, 2, Autosomal Recessive; Paired-Like (Aristaless) Homeobox 2a;

Function

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.

Biological Process

Dopaminergic neuron differentiation1 PublicationIC:BHF-UCL
Enteric nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Locus ceruleus developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Noradrenergic neuron differentiation1 PublicationNAS:BHF-UCL
Oculomotor nerve formationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of respiratory gaseous exchangeIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Somatic motor neuron differentiationIEA:Ensembl
Sympathetic nervous system developmentIEA:Ensembl
Trochlear nerve formationIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

Fibrosis of extraocular muscles, congenital, 2 (CFEOM2):
A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Congenital fibrosis of extraocular muscles type 2 may result from the defective development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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