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Rabbit Anti-PHOX2A Recombinant Antibody (BA0367) (CBMAB-0645CQ)

This product is a rabbit antibody that recognizes PHOX2A. The antibody BA0367 can be used for immunoassay techniques such as: IP, WB.
See all PHOX2A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0367
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide from residues in Human PHOX2A
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
paired-like homeobox 2a
Introduction
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Entrez Gene ID
Human401
Mouse11859
Rat116648
UniProt ID
HumanO14813
MouseQ62066
RatQ62782
Alternative Names
ARIX; FEOM2; NCAM2; PMX2A; CFEOM2
Function
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Biological Process
Dopaminergic neuron differentiation1 PublicationIC:BHF-UCL
Enteric nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Locus ceruleus developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Noradrenergic neuron differentiation1 PublicationNAS:BHF-UCL
Oculomotor nerve formationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of respiratory gaseous exchangeIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Somatic motor neuron differentiationIEA:Ensembl
Sympathetic nervous system developmentIEA:Ensembl
Trochlear nerve formationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Fibrosis of extraocular muscles, congenital, 2 (CFEOM2):
A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Congenital fibrosis of extraocular muscles type 2 may result from the defective development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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