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Mouse Anti-PI4K2B Recombinant Antibody (3B1) (CBMAB-P1733-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B1
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphatidylinositol 4-kinase beta
Introduction
PI4K2B (Phosphatidylinositol 4-Kinase Type 2 Beta) is a protein coding gene. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology annotations related to this gene include kinase activity and 1-phosphatidylinositol 4-kinase activity.
Entrez Gene ID
55300
UniProt ID
Q8TCG2
Alternative Names
NPIK; PI4K-BETA; PI4K92; PI4KBETA; PI4KIIIBETA; PIK4CB
Function
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459).
This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459).
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459).
Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
Biological Process
Endosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Golgi apparatus membrane
Endoplasmic reticulum membrane
Cell membrane
Early endosome membrane
Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1 (PubMed:12324459).
Association with early endosomes has not been confirmed (PubMed:11923287, PubMed:12324459).
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For research use only. Not intended for any clinical use.

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