PI4K2B

PI4K2B (Phosphatidylinositol 4-Kinase Type 2 Beta) is a protein coding gene. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology annotations related to this gene include kinase activity and 1-phosphatidylinositol 4-kinase activity.

Full Name

Phosphatidylinositol 4-kinase beta

Function

Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459).
This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459).
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459).
Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

Biological Process

Endosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytosol
Golgi apparatus membrane
Endoplasmic reticulum membrane
Cell membrane
Early endosome membrane
Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1 (PubMed:12324459).
Association with early endosomes has not been confirmed (PubMed:11923287, PubMed:12324459).