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Mouse Anti-PI4K2A Recombinant Antibody (3E1) (CBMAB-A6654-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3E1
Antibody Isotype
IgG2b, κ
Application
sELISA, ELISA

Basic Information

Immunogen
PI4KII (NP_060895.1, 383 a.a. ~ 477 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Phosphatidylinositol 4-Kinase Type 2 Alpha
Introduction
Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM
Entrez Gene ID
55361
UniProt ID
Q9BTU6
Alternative Names
DKFZp761G1923; PI4KII; PIK42A; RP11-548K23.6
Function
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Biological Process
Endosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Golgi apparatus, trans-Golgi network membrane
Membrane raft
Cell projection, dendrite
Cell junction, synapse, presynaptic cell membrane
Cell junction, synapse, synaptosome
Mitochondrion
Endosome
Cytoplasmic vesicle
Membrane
Cell membrane
Perikaryon
Cell projection, neuron projection
Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner.
PTM
Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization.
Ubiquitinated by ITCH; this does not lead to proteasomal degradation.
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For research use only. Not intended for any clinical use.

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