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Mouse Anti-PIDD1 Recombinant Antibody (B-5) (CBMAB-P1752-YC)

Provided herein is a Mouse monoclonal antibody against Human P53-Induced Death Domain Protein 1. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PIDD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
B-5
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
P53-Induced Death Domain Protein 1
Introduction
PIDD1 contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis.
Entrez Gene ID
55367
UniProt ID
Q9HB75
Alternative Names
P53-Induced Death Domain Protein 1; Leucine-Rich Repeat And Death Domain-Containing Protein; Leucine-Rich Repeats And Death Domain Containing; LRDD; PIDD; P53-Induced Death Domain-Containing Protein 1; P53-Induced Protein With A Death Domain; P53-Induced Death Domain Protein;
Function
Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900).
Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900).
Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestManual Assertion Based On ExperimentIMP:UniProtKB
Extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentTAS:UniProtKB
Protein autoprocessingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Enriched in the nucleus upon DNA damage.
PTM
Undergoes autoproteolytic processing whose extent either directs cells towards survival or apoptotic pathways (PubMed:17159900).
Autoproteolytically cleaved into two main fragments PIDD-N and PIDD-C (PubMed:17159900).
PIDD-C can be further processed into PIDD-CC, a processing which is enhanced by DNA damage (PubMed:17159900).
The cleavage producing PIDD-C is required for translocation of PIDD1 to the nucleus upon DNA damage and activation of NF-kappa-B (PubMed:17159900).
PIDD-CC mediates the interaction with CRADD and the cleavage producing PIDD-CC is required for the activation of CASP2 (PubMed:17159900).
PIDD-N remains associated with PIDD-C and PIDD-CC after cleavage (PubMed:17159900).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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