Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-PIDD1 Recombinant Antibody (CBT4604) (V2LY-0625-LY1257)


See all PIDD1 antibodies
Online Inquiry
Tested Data
Mouse Anti-PIDD1 Recombinant Antibody (CBT4604) (V2LY-0625-LY1257) in ELISA
Mouse Anti-PIDD1 Recombinant Antibody (CBT4604) (V2LY-0625-LY1257) in ELISA
Mouse Anti-PIDD1 Recombinant Antibody (CBT4604) (V2LY-0625-LY1257) in WB
Mouse Anti-PIDD1 Recombinant Antibody (CBT4604) (V2LY-0625-LY1257) in WB
Mouse Anti-PIDD1 Recombinant Antibody (CBT4604) (V2LY-0625-LY1257) in WB
Mouse Anti-PIDD1 Recombinant Antibody (CBT4604) (V2LY-0625-LY1257) in WB

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4604
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human PIDD1 (AA: 776-910) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
55367
UniProt ID
Q9HB75
Function
Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900).
Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900).
Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestManual Assertion Based On ExperimentIMP:UniProtKB
Extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentTAS:UniProtKB
Protein autoprocessingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Enriched in the nucleus upon DNA damage.
PTM
Undergoes autoproteolytic processing whose extent either directs cells towards survival or apoptotic pathways (PubMed:17159900).
Autoproteolytically cleaved into two main fragments PIDD-N and PIDD-C (PubMed:17159900).
PIDD-C can be further processed into PIDD-CC, a processing which is enhanced by DNA damage (PubMed:17159900).
The cleavage producing PIDD-C is required for translocation of PIDD1 to the nucleus upon DNA damage and activation of NF-kappa-B (PubMed:17159900).
PIDD-CC mediates the interaction with CRADD and the cleavage producing PIDD-CC is required for the activation of CASP2 (PubMed:17159900).
PIDD-N remains associated with PIDD-C and PIDD-CC after cleavage (PubMed:17159900).
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PIDD1 Recombinant Antibody (CBT4604)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry