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Mouse Anti-PIGS Recombinant Antibody (3F3) (CBMAB-P1768-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol Glycan Anchor Biosynthesis Class S. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PIGS antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
3F3
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PIGS (NP_149975.1, 450-518 aa) partial recombinant protein with GST tag.
Specificity
Human, Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphatidylinositol glycan anchor biosynthesis, class S
Introduction
PIGS is a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.
Entrez Gene ID
Human94005
Mouse276846
UniProt ID
HumanQ96S52
MouseQ6PD26
Alternative Names
Phosphatidylinositol Glycan Anchor Biosynthesis Class S; Phosphatidylinositol-Glycan Biosynthesis Class S Protein; Phosphatidylinositol Glycan, Class S; GPI Transamidase Subunit;
Function
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.
Biological Process
Attachment of GPI anchor to proteinManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Glycosylphosphatidylinositol biosynthesis defect 18 (GPIBD18):
An autosomal recessive disorder with onset in utero or early infancy and characterized by severe global developmental delay, seizures, hypotonia, weakness, ataxia, and dysmorphic facial features.
Topology
Cytoplasmic: 2-18
Helical: 19-39
Lumenal: 40-520
Helical: 521-541
Cytoplasmic: 542-555
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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