Mouse Anti-PIGS Recombinant Antibody (CBYC-P376) (CBMAB-P1770-YC)

Name: Mouse Anti-PIGS Recombinant Antibody (CBYC-P376)
SKU: CBMAB-P1770-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYC-P376

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 450-519

More Infomation

Target

Full Name

phosphatidylinositol glycan anchor biosynthesis, class S

Introduction

PIGS is a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.

Entrez Gene ID

94005

UniProt ID

Q96S52

Alternative Names

Phosphatidylinositol Glycan Anchor Biosynthesis Class S; Phosphatidylinositol-Glycan Biosynthesis Class S Protein; Phosphatidylinositol Glycan, Class S; GPI Transamidase Subunit;

Function

Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.

Biological Process

Attachment of GPI anchor to proteinManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Glycosylphosphatidylinositol biosynthesis defect 18 (GPIBD18):
An autosomal recessive disorder with onset in utero or early infancy and characterized by severe global developmental delay, seizures, hypotonia, weakness, ataxia, and dysmorphic facial features.

Topology

Cytoplasmic: 2-18
Helical: 19-39
Lumenal: 40-520
Helical: 521-541
Cytoplasmic: 542-555

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PIGS Recombinant Antibody (3F3) (CAT#: CBMAB-P1768-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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