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Mouse Anti-PIK3AP1 (AA 1-347) Recombinant Antibody (CBYY-1150) (CBMAB-1154-YY)

This product is mouse antibody that recognizes PIK3AP1. The antibody CBYY-1150 can be used for immunoassay techniques such as: IF, WB
See all PIK3AP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1150
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.96 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-347

Target

Full Name
phosphoinositide-3-kinase adaptor protein 1
Entrez Gene ID
118788
UniProt ID
Q6ZUJ8
Alternative Names
Phosphoinositide-3-Kinase Adaptor Protein 1; B-Cell Phosphoinositide 3-Kinase Adapter Protein 1; B-Cell Adapter For Phosphoinositide 3-Kinase; BCAP; Phosphoinositide 3-Kinase Adapter Protein 1; B Cell Adaptor Protein;
Function
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Biological Process
Positive regulation of phosphatidylinositol 3-kinase signalingISS:UniProtKB
Regulation of inflammatory responseISS:UniProtKB
Toll-like receptor 2 signaling pathwayISS:UniProtKB
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor 7 signaling pathwayISS:UniProtKB
Toll-like receptor 9 signaling pathwayISS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
PTM
Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity).
Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity).
Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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