Sign in or Register   Sign in or Register
  |  

PIK3AP1

PIK3AP1 has broad expression in spleen (RPKM 34.0), lymph node (RPKM 33.6) and 19 other tissues.
Full Name
phosphoinositide-3-kinase adaptor protein 1
Function
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Biological Process
Positive regulation of phosphatidylinositol 3-kinase signalingISS:UniProtKB
Regulation of inflammatory responseISS:UniProtKB
Toll-like receptor 2 signaling pathwayISS:UniProtKB
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor 7 signaling pathwayISS:UniProtKB
Toll-like receptor 9 signaling pathwayISS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
PTM
Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity).
Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity).
Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).

Anti-PIK3AP1 antibodies

Loading...

Mouse Anti-PIK3AP1 Recombinant Antibody (3C2) (CBMAB-A6671-LY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C2
Application*: SE, E

Mouse Anti-PIK3AP1 Recombinant Antibody (1C3) (CBMAB-P1780-YC)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C3
Application*: F, IC, IF, WB

Mouse Anti-PIK3AP1 Recombinant Antibody (5A1) (CBMAB-P1781-YC)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5A1
Application*: F, IF, WB

Mouse Anti-PIK3AP1 Recombinant Antibody (6H6) (CBMAB-P1782-YC)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6H6
Application*: F, WB

Mouse Anti-PIK3AP1 Recombinant Antibody (7G9) (CBMAB-P1783-YC)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 7G9
Application*: WB, F, IC, IF

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1148) (CBMAB-1152-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1148
Application*: F, IF, WB

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1149) (CBMAB-1153-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1149
Application*: F, IF, WB

Mouse Anti-PIK3AP1 (AA 1-347) Recombinant Antibody (CBYY-1150) (CBMAB-1154-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1150
Application*: IF, WB

Mouse Anti-PIK3AP1 (AA 1-347) Recombinant Antibody (CBYY-1151) (CBMAB-1155-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1151
Application*: F, IF, WB

Mouse Anti-PIK3AP1 (Center) Recombinant Antibody (CBYY-1153) (CBMAB-1157-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1153
Application*: F, WB

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1154) (CBMAB-1158-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1154
Application*: WB, F, IH, IC, P

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1155) (CBMAB-1159-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1155
Application*: IF, WB

Mouse Anti-PIK3AP1 (AA 249-276) Recombinant Antibody (CBYY-1156) (CBMAB-1160-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1156
Application*: F, IF, P, WB

Mouse Anti-PIK3AP1 (Center) Recombinant Antibody (CBYY-1157) (CBMAB-1161-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1157
Application*: F, IF, WB

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1158) (CBMAB-1162-YY)

Datasheet SDS
Target: PIK3AP1
Host: Mouse
Specificity: Human
Clone: CBYY-1158
Application*: WB, IP, IF, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare