PIK3AP1
PIK3AP1 has broad expression in spleen (RPKM 34.0), lymph node (RPKM 33.6) and 19 other tissues.
Full Name
phosphoinositide-3-kinase adaptor protein 1
Function
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Biological Process
Positive regulation of phosphatidylinositol 3-kinase signalingISS:UniProtKB
Regulation of inflammatory responseISS:UniProtKB
Toll-like receptor 2 signaling pathwayISS:UniProtKB
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor 7 signaling pathwayISS:UniProtKB
Toll-like receptor 9 signaling pathwayISS:UniProtKB
Regulation of inflammatory responseISS:UniProtKB
Toll-like receptor 2 signaling pathwayISS:UniProtKB
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor 7 signaling pathwayISS:UniProtKB
Toll-like receptor 9 signaling pathwayISS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Cell membrane
PTM
Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity).
Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity).
Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).
Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity).
Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).
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Anti-PIK3AP1 antibodies
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CompareTarget: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 7G9
Application*: WB, F, IC, IF
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6H6
Application*: F, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5A1
Application*: F, IF, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C3
Application*: F, IC, IF, WB
Target: PIK3AP1
Sensitivity: 0.0074 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C2
Application*: SE, E
Target: PIK3AP1
Host: Mouse
Specificity: Human
Clone: CBYY-1158
Application*: WB, IP, IF, E
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1157
Application*: F, IF, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1156
Application*: F, IF, P, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1155
Application*: IF, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1154
Application*: WB, F, IH, IC, P
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1153
Application*: F, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1151
Application*: F, IF, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1150
Application*: IF, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1149
Application*: F, IF, WB
Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1148
Application*: F, IF, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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