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PIK3AP1

PIK3AP1 has broad expression in spleen (RPKM 34.0), lymph node (RPKM 33.6) and 19 other tissues.
Full Name
phosphoinositide-3-kinase adaptor protein 1
Function
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Biological Process
Positive regulation of phosphatidylinositol 3-kinase signalingISS:UniProtKB
Regulation of inflammatory responseISS:UniProtKB
Toll-like receptor 2 signaling pathwayISS:UniProtKB
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor 7 signaling pathwayISS:UniProtKB
Toll-like receptor 9 signaling pathwayISS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
PTM
Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity).
Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity).
Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).
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Anti-PIK3AP1 antibodies

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Mouse Anti-PIK3AP1 Recombinant Antibody (7G9) (CBMAB-P1783-YC)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 7G9
Application*: WB, F, IC, IF
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (6H6) (CBMAB-P1782-YC)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6H6
Application*: F, WB
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (5A1) (CBMAB-P1781-YC)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5A1
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (1C3) (CBMAB-P1780-YC)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C3
Application*: F, IC, IF, WB
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (3C2) (CBMAB-A6671-LY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C2
Application*: SE, E
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1158) (CBMAB-1162-YY)

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Target: PIK3AP1
Host: Mouse
Specificity: Human
Clone: CBYY-1158
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-PIK3AP1 (Center) Recombinant Antibody (CBYY-1157) (CBMAB-1161-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1157
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-PIK3AP1 (AA 249-276) Recombinant Antibody (CBYY-1156) (CBMAB-1160-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1156
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1155) (CBMAB-1159-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1155
Application*: IF, WB
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1154) (CBMAB-1158-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1154
Application*: WB, F, IH, IC, P
Datasheet SDS

Mouse Anti-PIK3AP1 (Center) Recombinant Antibody (CBYY-1153) (CBMAB-1157-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1153
Application*: F, WB
Datasheet SDS

Mouse Anti-PIK3AP1 (AA 1-347) Recombinant Antibody (CBYY-1151) (CBMAB-1155-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1151
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-PIK3AP1 (AA 1-347) Recombinant Antibody (CBYY-1150) (CBMAB-1154-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1150
Application*: IF, WB
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1149) (CBMAB-1153-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1149
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-PIK3AP1 Recombinant Antibody (CBYY-1148) (CBMAB-1152-YY)

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Target: PIK3AP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1148
Application*: F, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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