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Mouse Anti-PIK3C2B Recombinant Antibody (1H4) (CBMAB-A6674-LY)

The product is antibody recognizes PIK3C2B. The antibody 1H4 immunoassay techniques such as: WB, ELISA.
See all PIK3C2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PIK3C2B (NP_002637, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphoinositide-3-kinase, class 2, beta polypeptide
Introduction
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq]
Entrez Gene ID
5287
UniProt ID
O00750
Alternative Names
C2-PI3K; DKFZp686G16234
Function
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253).
Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063).
May be involved in EGF and PDGF signaling cascades (PubMed:10805725).
Biological Process
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-3-phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Microsome
Cell membrane
Cytoplasm, cytosol
Nucleus
Endoplasmic reticulum
Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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