PIK3C2B

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq]

Full Name

phosphoinositide-3-kinase, class 2, beta polypeptide

Function

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253).
Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063).
May be involved in EGF and PDGF signaling cascades (PubMed:10805725).

Biological Process

Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-3-phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Microsome
Cell membrane
Cytoplasm, cytosol
Nucleus
Endoplasmic reticulum
Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.