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Mouse Anti-PIK3R2 Recombinant Antibody (18C7) (CBMAB-0837-CN)

This product is a mouse antibody that recognizes PIK3R2 of human. The antibody 18C7 can be used for immunoassay techniques such as: ELISA, MA.
See all PIK3R2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
18C7
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant SH2 domain of PIK3R2 (aa. 610-728)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PIK3R2
Introduction
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. This protein is a regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.
Entrez Gene ID
5296
UniProt ID
O00459
Alternative Names
p85; MPPH; P85B; MPPH1; p85-BETA
Function
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).
Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
Biological Process
B cell differentiation1 PublicationIC:ComplexPortal
Cellular glucose homeostasisISS:UniProtKB
Cellular response to insulin stimulusISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein import into nucleusISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Response to endoplasmic reticulum stressISS:UniProtKB
T cell differentiation1 PublicationIC:ComplexPortal
Cellular Location
cytosol
nucleus
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
Involvement in disease
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1):
A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
PTM
Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231).
Dephosphorylated by PTPRJ (PubMed:18348712).
Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).
Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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