Mouse Anti-PIK3R2 Recombinant Antibody (3H2842) (CBMAB-P1820-YC)

Name: Mouse Anti-PIK3R2 Recombinant Antibody (3H2842)
SKU: CBMAB-P1820-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3H2842

Application

IHC, IP, WB

Specificity

Cattle

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in 0.2 M Tris HCl pH 7.4, 5-10% fetal calf serum, 0.09% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PIK3R2

Introduction

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.

Entrez Gene ID

282308

UniProt ID

P23726

Alternative Names

Phosphoinositide-3-Kinase Regulatory Subunit 2; Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Beta; Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta); Phosphoinositide-3-Kinase Regulatory Subunit Beta; PtdIns-3-Kinase Regulatory Subunit P85-Beta; PI3K Regulatory Subunit Beta; PI3-Kinase Subunit P85-Beta; Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 2 (P85 Beta); Phosphatidylinositol 3-Kinase Regulatory Subunit Beta;

Function

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).
Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Biological Process

B cell differentiation1 PublicationIC:ComplexPortal
Cellular glucose homeostasisISS:UniProtKB
Cellular response to insulin stimulusISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein import into nucleusISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Response to endoplasmic reticulum stressISS:UniProtKB
T cell differentiation1 PublicationIC:ComplexPortal

Cellular Location

cytosol
nucleus
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA

Involvement in disease

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1):
A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.

PTM

Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231).
Dephosphorylated by PTPRJ (PubMed:18348712).
Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).
Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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