Human Recombinant PIK3R2 protein, His Tag (V2LY-0526-LY6179)

Name: Human Recombinant PIK3R2 protein, His Tag
SKU: V2LY-0526-LY6179
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant PIK3R2 protein, His Tag consist of Amino Acid: Full Length and predicts a molecular mass of 88 kDa.

Molecule Mass

88 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

PIK3R2

Function

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).
Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Biological Process

B cell differentiation1 PublicationIC:ComplexPortal
Cellular glucose homeostasisISS:UniProtKB
Cellular response to insulin stimulusISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein import into nucleusISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Response to endoplasmic reticulum stressISS:UniProtKB
T cell differentiation1 PublicationIC:ComplexPortal

Cellular Location

cytosol
nucleus
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA

Involvement in disease

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1):
A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.

PTM

Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231).
Dephosphorylated by PTPRJ (PubMed:18348712).
Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).
Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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