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Mouse Anti-PIK3R4 Recombinant Antibody (2E7) (CBMAB-A6684-LY)

The product is antibody recognizes PIK3R4. The antibody 2E7 immunoassay techniques such as: WB, ELISA.
See all PIK3R4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PIK3R4 (NP_055417, 1259 a.a. ~ 1358 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphoinositide-3-kinase, regulatory subunit 4
Entrez Gene ID
30849
UniProt ID
Q99570
Alternative Names
MGC102700; VPS15; p150
Function
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Biological Process
Autophagosome maturationManual Assertion Based On ExperimentIDA:ComplexPortal
Autophagy of peroxisomeManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to glucose starvationISS:UniProtKB
Early endosome to late endosome transportManual Assertion Based On ExperimentIDA:ComplexPortal
Late endosome to vacuole transportManual Assertion Based On ExperimentIBA:GO_Central
MacroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-3-phosphate biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Protein targeting to lysosome1 PublicationIC:ComplexPortal
Protein targeting to vacuoleManual Assertion Based On ExperimentIBA:GO_Central
Receptor catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of autophagyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of macroautophagyManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Late endosome
Cytoplasmic vesicle, autophagosome
Membrane
As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity).
PTM
Myristoylated.
Probably autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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