PIK3R4

PIK3R4 has ubiquitous expression in thyroid (RPKM 9.2), testis (RPKM 8.7) and 25 other tissues.

phosphoinositide-3-kinase, regulatory subunit 4

Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).

Autophagosome maturationManual Assertion Based On ExperimentIDA:ComplexPortal
Autophagy of peroxisomeManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to glucose starvationISS:UniProtKB
Early endosome to late endosome transportManual Assertion Based On ExperimentIDA:ComplexPortal
Late endosome to vacuole transportManual Assertion Based On ExperimentIBA:GO_Central
MacroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-3-phosphate biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Protein targeting to lysosome1 PublicationIC:ComplexPortal
Protein targeting to vacuoleManual Assertion Based On ExperimentIBA:GO_Central
Receptor catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of autophagyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of macroautophagyManual Assertion Based On ExperimentIDA:ComplexPortal

Late endosome
Cytoplasmic vesicle, autophagosome
Membrane
As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity).

Myristoylated.
Probably autophosphorylated.