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PIK3R4

PIK3R4 has ubiquitous expression in thyroid (RPKM 9.2), testis (RPKM 8.7) and 25 other tissues.
Full Name
phosphoinositide-3-kinase, regulatory subunit 4
Function
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Biological Process
Autophagosome maturationManual Assertion Based On ExperimentIDA:ComplexPortal
Autophagy of peroxisomeManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to glucose starvationISS:UniProtKB
Early endosome to late endosome transportManual Assertion Based On ExperimentIDA:ComplexPortal
Late endosome to vacuole transportManual Assertion Based On ExperimentIBA:GO_Central
MacroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-3-phosphate biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Protein targeting to lysosome1 PublicationIC:ComplexPortal
Protein targeting to vacuoleManual Assertion Based On ExperimentIBA:GO_Central
Receptor catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of autophagyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of macroautophagyManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Late endosome
Cytoplasmic vesicle, autophagosome
Membrane
As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity).
PTM
Myristoylated.
Probably autophosphorylated.
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Anti-PIK3R4 antibodies

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Mouse Anti-PIK3R4 Recombinant Antibody (2A6) (CBMAB-A6689-LY)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A6
Application*: WB, E
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (1H7) (CBMAB-A6688-LY)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 1H7
Application*: WB, E
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (1G12) (CBMAB-A6687-LY)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 1G12
Application*: WB, E
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (1D4) (CBMAB-A6686-LY)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D4
Application*: WB, E
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (2E7) (CBMAB-A6684-LY)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: WB, E
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (5D1) (CBMAB-P1827-YC)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D1
Application*: P
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (1B5) (CBMAB-P1826-YC)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B5
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (CBT3281) (V2LY-0625-LY1419)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3281
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-PIK3R4 Recombinant Antibody (CBT3138) (V2LY-0625-LY1394)

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Target: PIK3R4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3138
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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