Mouse Anti-PIK3R5 Recombinant Antibody (4G9) (CBMAB-P1830-YC)

Name: Mouse Anti-PIK3R5 Recombinant Antibody (4G9)
SKU: CBMAB-P1830-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4G9

Application

WB, IHC, IF

Immunogen

Full length human recombinant protein of human PIK3R5(NP_055123) produced in HEk293T cell

Specificity

Human, Dog, Rat, Monkey, Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phosphoinositide-3-Kinase Regulatory Subunit 5

Introduction

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.

Entrez Gene ID

Human	23533
Mouse	320207
Rat	497931
Dog	612805
Monkey	722027

UniProt ID

Human	Q8WYR1
Mouse	Q5SW28
Rat	D4A4I3
Dog	E2RLD1
Monkey	F6VTR8

Alternative Names

Phosphoinositide-3-Kinase Regulatory Subunit 5; Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Regulatory Subunit; PI3-Kinase P101 Subunit; PtdIns-3-Kinase P101; Protein FOAP-2; P101-PI3K; Phosphoinositide-3-Kinase, Regulatory Subunit 5;

Function

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).

Biological Process

G protein-coupled receptor signaling pathwayISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Phosphatidylinositol 3-kinase signalingISS:UniProtKB
Positive regulation of MAP kinase activityISS:UniProtKB
Positive regulation of protein kinase B signalingISS:UniProtKB

Cellular Location

Nucleus
Cytoplasm
Cell membrane
Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner.

Involvement in disease

Ataxia-oculomotor apraxia 3 (AOA3):
An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-PIK3R5 Recombinant Antibody (2C6) (CAT#: CBMAB-P1829-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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