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Mouse Anti-PIK3R5 Recombinant Antibody (5B1) (CBMAB-P1831-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphoinositide-3-Kinase Regulatory Subunit 5. The antibody can be used for immunoassay techniques, such as IF, IHC-P, WB.
See all PIK3R5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5B1
Antibody Isotype
IgG2a
Application
IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoinositide-3-Kinase Regulatory Subunit 5
Introduction
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
Entrez Gene ID
23533
UniProt ID
Q8WYR1
Alternative Names
Phosphoinositide-3-Kinase Regulatory Subunit 5; Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Regulatory Subunit; PI3-Kinase P101 Subunit; PtdIns-3-Kinase P101; Protein FOAP-2; P101-PI3K; Phosphoinositide-3-Kinase, Regulatory Subunit 5;
Function
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
Biological Process
G protein-coupled receptor signaling pathwayISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Phosphatidylinositol 3-kinase signalingISS:UniProtKB
Positive regulation of MAP kinase activityISS:UniProtKB
Positive regulation of protein kinase B signalingISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell membrane
Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner.
Involvement in disease
Ataxia-oculomotor apraxia 3 (AOA3):
An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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