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Mouse Anti-PIM2 Recombinant Antibody (9A5) (CBMAB-P1854-YC)

Provided herein is a Mouse monoclonal antibody against Human Pim-2 Proto-Oncogene, Serine/Threonine Kinase. The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IHC, IHC-P, IP, WB.
See all PIM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog
Clone
9A5
Antibody Isotype
IgG2a
Application
FC, ICC, IF, IHC, IHC-P, IP, WB

Basic Information

Immunogen
Full length human recombinant protein of human PIM2 (NP_006866) produced in HEK293T cell
Specificity
Human, Dog
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pim-2 Proto-Oncogene, Serine/Threonine Kinase
Introduction
PIM2 is a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.
Entrez Gene ID
Human11040
Dog442959
UniProt ID
HumanQ9P1W9
DogF1P8K8
Alternative Names
Pim-2 Proto-Oncogene, Serine/Threonine Kinase; Pim-2 Oncogene; EC 2.7.11.1; Pim-2h; Proto-Oncogene Pim-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase Pim-2;
Function
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Biological Process
Apoptotic processIEA:UniProtKB-KW
G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of autophagyISS:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingISS:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Cytoplasm
PTM
Autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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