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Mouse Anti-PIN4 Recombinant Antibody (7H2) (CBMAB-P1863-YC)

Provided herein is a Mouse monoclonal antibody against Human Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all PIN4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7H2
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4
Introduction
PIN4 is a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria.
Entrez Gene ID
5303
UniProt ID
Q9Y237
Alternative Names
Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4; Peptidyl-Prolyl Cis-Trans Isomerase Pin4; Peptidyl-Prolyl Cis/Trans Isomerase EPVH; Parvulin-14; Parvulin-17; Parvulin; HPar14; HPar17; PAR14; PAR17; HEPVH; Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin);
Function
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.
Isoform 2 binds to double-stranded DNA.
Biological Process
rRNA processingIMP:UniProtKB
Cellular Location
Isoform 1
Nucleus, nucleolus
Cytoplasm, cytoskeleton, spindle
Cytoplasm
Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.
Isoform 2
Mitochondrion
Mitochondrion matrix
Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.
PTM
Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.
Isoform 2 is sumoylated with SUMO2 and SUMO3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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