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Mouse Anti-PISD Recombinant Antibody (2C1) (CBMAB-D2162-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Phosphatidylserine Decarboxylase (PISD). The antibody can be used for immunoassay techniques, such as WB.
See all PISD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C1
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 80-340

Target

Full Name
Phosphatidylserine decarboxylase
Introduction
PISD catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. PISD is active in phospholipid metabolism and interorganelle trafficking of phosphatidylserine.
Entrez Gene ID
23761
UniProt ID
Q9UG56
Alternative Names
PSD; PSDC; PSSC; DJ858B16; dJ858B16.2
Function
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161).
Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Biological Process
Mitochondrial protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylethanolamine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Protein autoprocessingIEA:UniProtKB-UniRule
Regulation of mitochondrion organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Phosphatidylserine decarboxylase beta chain
Mitochondrion inner membrane
Phosphatidylserine decarboxylase alpha chain
Mitochondrion inner membrane
Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.
Involvement in disease
Liberfarb syndrome (LIBF):
An autosomal recessive multisystem disorder affecting the eye, ear, bone, and brain development. Clinical features include early-onset retinal degeneration, congenital cataracts, sensorineural hearing loss, microcephaly, intellectual disability, white matter changes, mild facial dysmorphism, and skeletal dysplasia with platyspondyly, scoliosis and short stature.
Topology
Mitochondrial matrix: 53-63
Helical: 64-82
Mitochondrial intermembrane: 83-409
PTM
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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