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Mouse Anti-PITPNB Recombinant Antibody (6H10) (CBMAB-P1895-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6H10
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
PITPNB is a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum.
Entrez Gene ID
23760
UniProt ID
P48739
Alternative Names
PI-TP-beta; PtdInsTP; VIB1B
Function
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109).
Also catalyzes the transfer of sphingomyelin (By similarity).
Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109).
Biological Process
Lipid metabolic process1 PublicationNAS:ProtInc
Nucleus organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Phospholipid transportManual Assertion Based On ExperimentIDA:BHF-UCL
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Golgi apparatus
Golgi apparatus membrane
Endoplasmic reticulum membrane
PTM
Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.
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For research use only. Not intended for any clinical use.

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