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PITPNB

The protein encoded by this gene is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. [provided by RefSeq]

Full Name

phosphatidylinositol transfer protein, beta

Function

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109).
Also catalyzes the transfer of sphingomyelin (By similarity).
Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109).

Biological Process

Lipid metabolic process1 PublicationNAS:ProtInc
Nucleus organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Phospholipid transportManual Assertion Based On ExperimentIDA:BHF-UCL
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Golgi apparatus
Golgi apparatus membrane
Endoplasmic reticulum membrane

PTM

Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.

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Anti-PITPNB antibodies

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Mouse Anti-PITPNB Recombinant Antibody (E-2) (CBMAB-P1896-YC)

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Target: PITPNB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: E-2

Application*: WB, IP, IF, E

Mouse Anti-PITPNB Recombinant Antibody (6H10) (CBMAB-P1895-YC)

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Target: PITPNB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6H10

Application*: WB, IH

Mouse Anti-PITPNB Recombinant Antibody (3D3) (CBMAB-P1894-YC)

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Target: PITPNB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3D3

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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