PITPNB

The protein encoded by this gene is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. [provided by RefSeq]

phosphatidylinositol transfer protein, beta

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109).
Also catalyzes the transfer of sphingomyelin (By similarity).
Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109).

Lipid metabolic process1 PublicationNAS:ProtInc
Nucleus organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Phospholipid transportManual Assertion Based On ExperimentIDA:BHF-UCL
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB

Golgi apparatus
Golgi apparatus membrane
Endoplasmic reticulum membrane

Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.