Mouse Anti-PJA2 Recombinant Antibody (1G11) (CBMAB-P1913-YC)

Name: Mouse Anti-PJA2 Recombinant Antibody (1G11)
SKU: CBMAB-P1913-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1G11

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

praja ring finger 2

Introduction

PJA2 (Praja Ring Finger Ubiquitin Ligase 2) is a protein coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology annotations related to this gene include ligase activity and protein kinase A catalytic subunit binding. An important paralog of the gene is PJA1.

Entrez Gene ID

9867

UniProt ID

O43164

Alternative Names

Neurodap1; RNF131

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).

Biological Process

Hippo signalingIEA:InterPro
Inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Long-term memoryISS:UniProtKB
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of toll-like receptor 2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of macrophage activationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein kinase A signalingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus membrane
Cell junction, synapse
Cell junction, synapse, postsynaptic density
Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity).
Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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