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Mouse Anti-PJA2 Recombinant Antibody (1G11) (CBMAB-P1913-YC)

Provided herein is a Mouse monoclonal antibody against Human Praja ring finger ubiquitin ligase 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PJA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
praja ring finger 2
Introduction
PJA2 (Praja Ring Finger Ubiquitin Ligase 2) is a protein coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology annotations related to this gene include ligase activity and protein kinase A catalytic subunit binding. An important paralog of the gene is PJA1.
Entrez Gene ID
9867
UniProt ID
O43164
Alternative Names
Neurodap1; RNF131
Function
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).
Biological Process
Hippo signalingIEA:InterPro
Inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Long-term memoryISS:UniProtKB
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of toll-like receptor 2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of macrophage activationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein kinase A signalingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus membrane
Cell junction, synapse
Cell junction, synapse, postsynaptic density
Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity).
Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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