PJA2

PJA2 (Praja Ring Finger Ubiquitin Ligase 2) is a protein coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology annotations related to this gene include ligase activity and protein kinase A catalytic subunit binding. An important paralog of the gene is PJA1.

Full Name

praja ring finger 2

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).

Biological Process

Hippo signalingIEA:InterPro
Inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Long-term memoryISS:UniProtKB
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of toll-like receptor 2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of macrophage activationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein kinase A signalingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus membrane
Cell junction, synapse
Cell junction, synapse, postsynaptic density
Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity).
Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.