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Mouse Anti-PKP1 Recombinant Antibody (19F10) (CBMAB-P1969-YC)

Provided herein is a Mouse monoclonal antibody against Human Plakophilin 1. The antibody can be used for immunoassay techniques, such as WB, IP, IHC-P, IHC-Fr.
See all PKP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
19F10
Antibody Isotype
IgG1
Application
WB, IP, IHC-P, IHC-Fr

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Plakophilin 1
Introduction
PKP1 is a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome.
Entrez Gene ID
Human5317
Mouse18772
UniProt ID
HumanQ13835
MouseP97350
Alternative Names
B6P
Function
Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyManual Assertion Based On ExperimentIBA:GO_Central
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of mRNA catabolic processManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:CAFA
Signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Isoform 1
Nucleus
Cell junction, desmosome
Nucleus
Involvement in disease
Ectodermal dysplasia-skin fragility syndrome (EDSFS):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting skin, hair and nails. There is no evidence of significant abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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