Human PKP1 ELISA Kit (V2LY-0626-LY2859)

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Tested Data
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Basic Information

Sensitivity
0.011 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
82.9 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Plakophilin 1
Function
Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyManual Assertion Based On ExperimentIBA:GO_Central
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of mRNA catabolic processManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:CAFA
Signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Isoform 1
Nucleus
Cell junction, desmosome
Nucleus
Involvement in disease
Ectodermal dysplasia-skin fragility syndrome (EDSFS):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting skin, hair and nails. There is no evidence of significant abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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