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Mouse Anti-PKP4 Recombinant Antibody (1B11) (CBMAB-A6760-LY)

The product is antibody recognizes PKP4. The antibody 1B11 immunoassay techniques such as: WB, ELISA.
See all PKP4 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PKP4 (NP_001005476, 12 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
plakophilin 4
Introduction
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq]
Entrez Gene ID
UniProt ID
Alternative Names
FLJ31261; FLJ42243; p0071
Function
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
Biological Process
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyISS:UniProtKB
Cell-cell signaling1 PublicationNAS:UniProtKB
Positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell adhesion1 PublicationNAS:UniProtKB
Cellular Location
Cell junction, desmosome
Cytoplasm, cytoskeleton, spindle
Midbody
Cell membrane
Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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