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Mouse Anti-PKP4 Recombinant Antibody (406.3.1) (CBMAB-P1974-YC)

Provided herein is a Mouse monoclonal antibody against Human Plakophilin 4. The antibody can be used for immunoassay techniques, such as IHC-Fr, ICC, IF, IHC-P, WB.
See all PKP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Cattle, Mouse
Clone
406.3.1
Antibody Isotype
IgG1
Application
IHC-Fr, ICC, IF, IHC-P, WB

Basic Information

Specificity
Human, Cattle, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 793-816

Target

Full Name
plakophilin 4
Introduction
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function.
Entrez Gene ID
Human8502
Mouse227937
Cattle281406
UniProt ID
HumanQ99569
MouseQ68FH0
CattleF1MJ11
Alternative Names
p0071
Function
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
Biological Process
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyISS:UniProtKB
Cell-cell signaling1 PublicationNAS:UniProtKB
Positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell adhesion1 PublicationNAS:UniProtKB
Cellular Location
Cell junction, desmosome
Cytoplasm, cytoskeleton, spindle
Midbody
Cell membrane
Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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