Mouse Anti-PKP4 Recombinant Antibody (406.3.1) (CBMAB-P1974-YC)

Name: Mouse Anti-PKP4 Recombinant Antibody (406.3.1)
SKU: CBMAB-P1974-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

406.3.1

Application

IHC-Fr, ICC, IF, IHC-P, WB

Specificity

Human, Cattle, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 793-816

More Infomation

Target

Full Name

plakophilin 4

Introduction

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function.

Entrez Gene ID

Human	8502
Mouse	227937
Cattle	281406

UniProt ID

Human	Q99569
Mouse	Q68FH0
Cattle	F1MJ11

Alternative Names

p0071

Function

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.

Biological Process

Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyISS:UniProtKB
Cell-cell signaling1 PublicationNAS:UniProtKB
Positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell adhesion1 PublicationNAS:UniProtKB

Cellular Location

Cell junction, desmosome
Cytoplasm, cytoskeleton, spindle
Midbody
Cell membrane
Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-PKP4 Recombinant Antibody (4H7) (CAT#: CBMAB-A6762-LY)

Mouse Anti-PKP4 Recombinant Antibody (1B11) (CAT#: CBMAB-A6760-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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