Mouse Anti-PLA2G4A Recombinant Antibody (10G5) (CBMAB-P1995-YC)

phospholipase A2, group IVA (cytosolic, calcium-dependent)

PLA2G4A (Phospholipase A2 Group IVA) is a protein coding gene. Diseases associated with PLA2G4A include Cryptogenic Multifocal Ulcerous Stenosing Enteritis and Cytosolic Phospholipase-A2 Alpha Deficiency Associated Bleeding Disorder. Among its related pathways are p38 MAPK Signaling Pathway (WikiPathways) and Immune response Fc epsilon RI pathway. Gene Ontology annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of the gene is PLA2G4E.

PLA2G4; cPLA2; cPLA2-alpha

Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121, PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:27642067, PubMed:18451993).
Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity).
Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:7794891, PubMed:8619991, PubMed:9425121, PubMed:10358058, PubMed:17472963, PubMed:18451993).
Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:18451993, PubMed:7794891, PubMed:9425121, PubMed:10358058, PubMed:17472963).
In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067).
Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891).
Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805).
Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891).

Arachidonic acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Arachidonic acid secretionIEA:Ensembl
Cellular response to antibioticIEA:Ensembl
Glycerol metabolic processIEA:UniProtKB-KW
Glycerophospholipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Icosanoid metabolic process1 PublicationNAS:UniProtKB
Leukotriene biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Monoacylglycerol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylcholine acyl-chain remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylcholine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylglycerol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Platelet activating factor biosynthetic process1 PublicationNAS:UniProtKB
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of platelet activationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of prostaglandin secretionIEA:Ensembl
Positive regulation of T-helper 1 type immune responseIEA:Ensembl
Prostaglandin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationIEA:Ensembl

Cytoplasm
Golgi apparatus membrane
Nucleus envelope
Translocates to intracellular membranes in a calcium-dependent way.

Gastrointestinal ulceration, recurrent, with dysfunctional platelets (GURDP):
An autosomal recessive disorder characterized by recurrent gastrointestinal mucosal ulcers, gastrointestinal bleeding, chronic anemia, iron deficiency, and abdominal pain. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis.

Phosphorylated at both Ser-505 and Ser-727 in response to mitogenic stimuli.