Mouse Anti-PLA2G7 Recombinant Antibody (A921) (CBMAB-AP4313LY)

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
A921
Application
IHC, WB
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
phospholipase A2 group VII
Entrez Gene ID
UniProt ID
Function
SAB-42042
Biological Process
Lipid oxidationManual Assertion Based On ExperimentIDA:BHF-UCL
Low-density lipoprotein particle remodelingManual Assertion Based On ExperimentIDA:BHF-UCL
Peptide hormone processingTAS:Reactome
Phosphatidylcholine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Plasma lipoprotein particle oxidationManual Assertion Based On ExperimentIDA:BHF-UCL
Platelet activating factor catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Platelet activating factor metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of monocyte chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Secreted, extracellular space
Associates with both LDL and HDL particles in plasma (PubMed:11590221, PubMed:12821559, PubMed:18434304, PubMed:10066756).
Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559).
Involvement in disease
Platelet-activating factor acetylhydrolase deficiency (PAFAD):
An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms.
Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Atopic hypersensitivity (ATOPY):
A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.
PTM
N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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