Mouse Recombinant PLA2G7 protein, His Tag (V2LY-0526-LY8786)
Compare
Online Inquiry
Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:2040620, PubMed:10504265).
Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620).
Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782).
Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10504265, PubMed:10066756, PubMed:7592717, PubMed:11590221, PubMed:7700381, PubMed:18434304, PubMed:16371369, PubMed:8675689, PubMed:8624782).
Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (PubMed:2040620, PubMed:7700381).
As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529).
Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369).
Low-density lipoprotein particle remodelingManual Assertion Based On ExperimentIDA:BHF-UCL
Peptide hormone processingTAS:Reactome
Phosphatidylcholine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Plasma lipoprotein particle oxidationManual Assertion Based On ExperimentIDA:BHF-UCL
Platelet activating factor catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Platelet activating factor metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of monocyte chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Associates with both LDL and HDL particles in plasma (PubMed:11590221, PubMed:12821559, PubMed:18434304, PubMed:10066756).
Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559).
An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms.
Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Atopic hypersensitivity (ATOPY):
A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon
$30 eGift Card
Submit a review
Loading...
Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant PLA2G7 protein, His Tag (CAT#: V2LY-0526-LY6220)
Human PLA2G7 ELISA Kit (2) (CAT#: V2LY-0626-LY4034)
Related Products
Mouse Anti-PLA2G7 Recombinant Antibody (2A1B6) (CAT#: CBMAB-R4244-CN)
Mouse Anti-PLA2G7 Monoclonal Antibody (CBFYR0679) (CAT#: CBMAB-R0679-FY)
Mouse Anti-PLA2G7 Recombinant Antibody (CBT3134) (CAT#: V2LY-0625-LY1326)
Mouse Anti-PLA2G7 Recombinant Antibody (CBYC-P416) (CAT#: CBMAB-P2003-YC)
Mouse Anti-PLA2G7 Recombinant Antibody (CBYJL-2307) (CAT#: CBMAB-L2598-YJ)
Mouse Anti-PLA2G7 Recombinant Antibody (CBT4107) (CAT#: V2LY-0625-LY1325)
Mouse Anti-PLA2G7 Recombinant Antibody (IHC407) (CAT#: CBMAB-MA201-YC)
Human Recombinant PLA2G7 protein, His Tag (CAT#: V2LY-0526-LY6220)
Mouse Anti-PLA2G7 Monoclonal Antibody (CBFYR0680) (CAT#: CBMAB-R0680-FY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
Online InquiryContact us
