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Mouse Anti-PLEKHO1 Recombinant Antibody (1C7) (CBMAB-P2105-YC)

Provided herein is a Mouse monoclonal antibody against Human Pleckstrin Homology Domain Containing O1. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P.
See all PLEKHO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C7
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P

Basic Information

Immunogen
PLEKHO1 (AAH10149, 1-410 aa) full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pleckstrin homology domain containing, family O member 1
Introduction
PLEKHO1 (Pleckstrin Homology Domain Containing O1) is a protein coding gene. Diseases associated with PLEKHO1 include Colonic Benign Neoplasm. An important paralog of the gene is PLEKHO2.
Entrez Gene ID
51177
UniProt ID
Q53GL0
Alternative Names
CKIP-1; CKIP1; OC120; JBP
Function
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Biological Process
Lamellipodium morphogenesisIEA:Ensembl
Myoblast fusionIEA:Ensembl
Myoblast migrationIEA:Ensembl
Regulation of cell shapeIEA:Ensembl
Regulation of myoblast fusionManual Assertion Based On ExperimentIBA:GO_Central
PTM
C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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