PLEKHO1

PLEKHO1 (Pleckstrin Homology Domain Containing O1) is a protein coding gene. Diseases associated with PLEKHO1 include Colonic Benign Neoplasm. An important paralog of the gene is PLEKHO2.

Full Name

pleckstrin homology domain containing, family O member 1

Function

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Biological Process

Lamellipodium morphogenesisIEA:Ensembl
Myoblast fusionIEA:Ensembl
Myoblast migrationIEA:Ensembl
Regulation of cell shapeIEA:Ensembl
Regulation of myoblast fusionManual Assertion Based On ExperimentIBA:GO_Central

PTM

C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.