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Rabbit Anti-PLIN1 Recombinant Antibody (D1D8) (CBMAB-P2123-YC)

Provided herein is a Rabbit monoclonal antibody against Human Perilipin 1. The antibody can be used for immunoassay techniques, such as WB, IP, IHC-P, IF, IF.
See all PLIN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
D1D8
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF, IF

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Perilipin 1
Introduction
PLIN1 coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene.
Entrez Gene ID
Human5346
Mouse103968
UniProt ID
HumanO60240
MouseQ8CGN5
Alternative Names
FPLD4; PERI; PLIN
Function
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Biological Process
Cellular response to coldIEA:Ensembl
Lipid catabolic processIEA:Ensembl
Lipid metabolic process1 PublicationNAS:UniProtKB
Cellular Location
Endoplasmic reticulum
Lipid droplet
Lipid droplet surface-associated.
Involvement in disease
Lipodystrophy, familial partial, 4 (FPLD4):
A form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension.
PTM
Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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