PLIN1

PLIN1 coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene.
Full Name
Perilipin 1
Function
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Biological Process
Cellular response to coldIEA:Ensembl
Lipid catabolic processIEA:Ensembl
Lipid metabolic process1 PublicationNAS:UniProtKB
Cellular Location
Endoplasmic reticulum
Lipid droplet
Lipid droplet surface-associated.
Involvement in disease
Lipodystrophy, familial partial, 4 (FPLD4):
A form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension.
PTM
Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).
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Anti-PLIN1 antibodies

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Mouse Anti-PLIN1 Recombinant Antibody (4G1) (CBMAB-A6801-LY)

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Target: PLIN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G1
Application*: WB, E
Datasheet SDS

Mouse Anti-PLIN1 Recombinant Antibody (PERI 112.17) (CBMAB-P2125-YC)

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Target: PLIN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Rat
Clone: PERI 112.17
Application*: IC, IH, WB
Datasheet SDS

Mouse Anti-PLIN1 Recombinant Antibody (PERI) (CBMAB-P2124-YC)

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Target: PLIN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Cattle, Rat
Clone: PERI
Application*: IF, IH, WB
Datasheet SDS

Rabbit Anti-PLIN1 Recombinant Antibody (D1D8) (CBMAB-P2123-YC)

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Target: PLIN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D1D8
Application*: WB, IP, P, IF, IF
Datasheet SDS

Mouse Anti-PLIN1 Recombinant Antibody (4G1) (CBMAB-P2122-YC)

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Target: PLIN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G1
Application*: E, WB
Datasheet SDS

Human PLIN1 ELISA Kit (V2LY-0626-LY3699)

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Target: PLIN1
Sensitivity: 0.043 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Plin1 ELISA Kit (V2LY-0626-LY1345)

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Target: Plin1
Sensitivity: 0.0049 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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