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Mouse Anti-PLOD2 Recombinant Antibody (CBYJL-2311) (CBMAB-L2603-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2). The antibody can be used for immunoassay techniques, such as WB, IP.
See all PLOD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2311
Antibody Isotype
IgG2b
Application
WB, IP

Basic Information

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Lysine Hydroxylase 2/PLOD2, Ala26-Pro758, Accession # NP_891988.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2
Introduction
PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
5352
UniProt ID
O00469
Alternative Names
LH2; TLH; BRKS2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; lysine hydroxylase 2; lysyl hydroxlase 2; lysyl hydroxylase 2; procollagen-lysine 5-dioxygenase; telopeptide lysyl hydroxylase; EC 1.14.11.4
Function
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Biological Process
Hydroxylysine biosynthetic processManual Assertion Based On ExperimentIDA:CAFA
Peptidyl-lysine hydroxylationManual Assertion Based On ExperimentIDA:CAFA
Protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Response to hypoxiaManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Rough endoplasmic reticulum membrane
Involvement in disease
Bruck syndrome 2 (BRKS2):
An autosomal recessive disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia. It is distinguished from osteogenesis imperfecta by the absence of hearing loss and dentinogenesis imperfecta, and by the presence of clubfoot and congenital joint limitations.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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