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PLOD2

PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome.
Full Name
Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2
Function
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Biological Process
Hydroxylysine biosynthetic processManual Assertion Based On ExperimentIDA:CAFA
Peptidyl-lysine hydroxylationManual Assertion Based On ExperimentIDA:CAFA
Protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Response to hypoxiaManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Rough endoplasmic reticulum membrane
Involvement in disease
Bruck syndrome 2 (BRKS2):
An autosomal recessive disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia. It is distinguished from osteogenesis imperfecta by the absence of hearing loss and dentinogenesis imperfecta, and by the presence of clubfoot and congenital joint limitations.
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Anti-PLOD2 antibodies

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Mouse Anti-PLOD2 Recombinant Antibody (1A12) (CBMAB-P2154-YC)

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Target: PLOD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A12
Application*: WB
Datasheet SDS

Mouse Anti-PLOD2 Recombinant Antibody (8A4) (CBMAB-P2158-YC)

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Target: PLOD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8A4
Application*: WB
Datasheet SDS

Mouse Anti-PLOD2 Recombinant Antibody (7G5) (CBMAB-P2157-YC)

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Target: PLOD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7G5
Application*: P, WB
Datasheet SDS

Mouse Anti-PLOD2 Recombinant Antibody (CBYC-P449) (CBMAB-P2156-YC)

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Target: PLOD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-P449
Application*: IP, WB
Datasheet SDS

Mouse Anti-PLOD2 Recombinant Antibody (1H9E1) (CBMAB-P2155-YC)

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Target: PLOD2
Host: Mouse
Antibody Isotype: IgA
Specificity: Human
Clone: 1H9E1
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-PLOD2 Recombinant Antibody (CBYJL-2312) (CBMAB-L2604-YJ)

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Target: PLOD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2312
Application*: WB, P
Datasheet SDS

Mouse Anti-PLOD2 Recombinant Antibody (CBYJL-2311) (CBMAB-L2603-YJ)

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Target: PLOD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-2311
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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