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Mouse Anti-PLPPR4 Recombinant Antibody (CBYCL-625) (CBMAB-L0526-YC)

Provided herein is a Mouse monoclonal antibody against Human PLPPR4. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PLPPR4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-625
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Lyophilized from PBS, pH7.4, with 50% glycerol, 5% trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phospholipid phosphatase related 4
Introduction
PLPPR4 belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting.
Entrez Gene ID
9890
UniProt ID
Q7Z2D5
Alternative Names
LPPR4; LPR4; PHP1; PRG-1; PRG1
Function
Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity).
Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity).
Biological Process
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayISS:UniProtKB
Inner ear developmentIEA:Ensembl
Lipid import into cellISS:UniProtKB
Phospholipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of synaptic transmission, glutamatergicISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Postsynaptic density membrane
PTM
O-glycosylated. Probably at Ser-346.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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