Mouse Anti-PLPPR4 Recombinant Antibody (CBYCL-625) (CBMAB-L0526-YC)

Name: Mouse Anti-PLPPR4 Recombinant Antibody (CBYCL-625)
SKU: CBMAB-L0526-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYCL-625

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

Lyophilized from PBS, pH7.4, with 50% glycerol, 5% trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phospholipid phosphatase related 4

Introduction

PLPPR4 belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting.

Entrez Gene ID

9890

UniProt ID

Q7Z2D5

Alternative Names

LPPR4; LPR4; PHP1; PRG-1; PRG1

Function

Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity).
Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity).

Biological Process

AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayISS:UniProtKB
Inner ear developmentIEA:Ensembl
Lipid import into cellISS:UniProtKB
Phospholipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of synaptic transmission, glutamatergicISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Postsynaptic density membrane

PTM

O-glycosylated. Probably at Ser-346.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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