PLPPR4

PLPPR4 hydrolyzes lysophosphatidic acid (LPA). PLPPR4 facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons it acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.

Full Name

phospholipid phosphatase related 4

Function

Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity).
Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity).

Biological Process

AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayISS:UniProtKB
Inner ear developmentIEA:Ensembl
Lipid import into cellISS:UniProtKB
Phospholipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of synaptic transmission, glutamatergicISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Postsynaptic density membrane

PTM

O-glycosylated. Probably at Ser-346.